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The Effect of Enamel Matrix Derivatives on the Collagen Formation by Human Periodontal Ligament Stem Cells both in vitro and in vivo Analysis
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:Cha Jae-Kook
:Oh Sang-Yeob/:Oh Sang-Yeob/:Kim Dong-Jun/:Park So-Yon/:Cho Kyoo-Sung/:Kim Chang-Sung
KMID : 0362720150530120935
Abstract
¸ñÀû: ¹ý¶û±âÁú À¯µµÃ¼(EMD)°¡ »ç¶÷ Ä¡ÁÖÀδë Áٱ⼼Æ÷(hPDLSC)ÀÇ Á¶Á÷ Çü¼º´É¿¡ ¹ÌÄ¡´Â ¿µÇâÀ» in vitro¿Í in vivo ºÐ¼® ¸ðµ¨À» ÀÌ¿ëÇØ Æò°¡ÇÑ´Ù.
Àç·á ¹× ¹æ¹ý: hPDLSC¸¦ ¹è¾çÇÏ¿© ¿î¹Ýü¿Í ÇÔ²² ¸é¿ª ¾ïÁ¦µÈ Á㠵 À̽ÄÇÏ¿´´Ù; (1)´ëÁ¶±º: EMD óġÇÏÁö ¾ÊÀº ¿î¹Ýü¿¡ ½É¾îÁø hPDLSC ±º (EMD-/hPDLSC+), (2)½ÇÇ豺: EMD óġÇÑ ¿î¹Ýü¿¡ ½É¾îÁø hPDLSC±º (EMD+/hPDLSC+). °¢ ±º´ç 5¸¶¸®¾¿ ½ÃÇàÇÏ°í 8ÁÖ ÈÄ Èñ»ýÇÏ¿´´Ù. Á¶Á÷ÇÐÀû, Á¶Á÷°èÃøÇÐÀû ºÐ¼®À» ÅëÇØ Çü¼ºµÈ ¹é¾ÇÁúÀÇ ¸éÀû°ú ¹é¾Ç¼¼Æ÷ÀÇ ¼ö ±×¸®°í »þÇÇ ¼¶À¯ÀÇ ¼ö¸¦ °èÃøÇÏ¿´À¸¸ç ¸é¿ªÁ¶Á÷ÈÇÐÀû ºÐ¼®À» ÅëÇØ ¹é¾ÇÁú°ú ±³¿øÁú Çü¼ºÀ» Æò°¡ÇÏ¿´´Ù. ¶ÇÇÑ in vitro¿¡¼ hPDLSCÀÇ ¼ö¿ë¼º ±³¿øÁú°ú glycosaminoglycan Çü¼º¿¡ ´ëÇÑ EMDÀÇ È¿°ú¸¦ ºÐ¼®ÇÏ¿´´Ù.
°á°ú: Á¶Á÷ÇÐÀû ºÐ¼®¿¡¼ ±³¿øÁú¼º Ä¡ÁÖ Àδë Á¶Á÷ÀÌ ½ÇÇ豺¿¡¼ ÇöÀúÇÏ°Ô ¸¹ÀÌ »ý¼ºµÈ °ÍÀ» °üÂûÇÒ ¼ö ÀÖ¾ú´Ù. Çü¼ºµÈ ¹é¾ÇÁúÀÇ ¸éÀû°ú ¹é¾Ç¼¼Æ÷ÀÇ ¼ö´Â ±º °£ Â÷ÀÌ°¡ ¾ø¾úÀ¸³ª, »õ·Ó°Ô Çü¼ºµÈ »þÇÇ ¼¶À¯ÀÇ ¼ö´Â ½ÇÇ豺¿¡¼ ´ëÁ¶±ºº¸´Ù À¯ÀÇÇÏ°Ô ¸¹¾Ò´Ù(p<0.05). ±³¿øÁú Çü¼º¿¡ ´ëÇÑ ¸é¿ªÁ¶Á÷ ÈÇÐÀû ºÐ¼® °á°ú, ½ÇÇ豺¿¡¼ I, IIIÇü ±³¿øÁú°ú hydroxyprolineÀÇ ¹ßÇöÀÌ ³ô¾Ò´Ù. ¶ÇÇÑ in vitro¿¡¼ hPDLSC¿¡ ÀÇÇÑ ¼ö¿ë¼º ±³¿øÁú°ú glycosaminoglycan Çü¼ºÀÌ EMDÀÇ ³óµµ¿¡ ºñ·ÊÇÏ¿© Áõ°¡ÇÏ¿´´Ù (p<0.05).
°á·Ð: EMD´Â hPDLSC¿¡ ÀÇÇÑ »þÇÇ ¼¶À¯ ¹× ±³¿øÁú »ý¼ºÀ» Áõ°¡½ÃÅ°°í, ÀÌ´Â »õ·Î¿î ¹é¾ÇÁúÀÇ ±â´ÉÀû ºÎÂø°ú Ä¡ÁÖÁ¶Á÷ Àç»ý¿¡ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù.
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enamel matrix proteins; mesenchymal stromal cells; periodontal ligament; periodontium; regeneration; tissue engineering
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